Lipodissolve, also known as injection lipolysis, is a fat treatment method in which small deposits (usually .25 to .5ccs per injection) of a solution are placed immediately under the skin. (.5cm) When this solution comes into contact with fat, and it has a zone of diffusion of about 1 cm. from the injection site, a ‘fight’ takes place known as inflammation. This inflammatory reaction helps break down the walls of the fat cells allowing their stored fat to be released. While there is some debate as to what actually happens to fat that is released, it appears that it is removed by the bloodstream and carried to the liver where it is broken down and eliminated as waste products.

Most LipoDissolve solutions  use a mixture of synthetic emulsifying chemicals which are well tolerated by the body. Lecithin, also known as phosphatidycholine, and cholic acid (bile salt) are always the two main ingredients. Both have emulsifying properties to break down fat cell walls and there is some debate also as to which one is really the most effective at doing so. Since these LipoDissolve solutions are not FDA-approved, they are mixed and distributed by compounding pharmacies. (which are also not FDA regulated) The compounding pharmacy industry is usually unknown to most of the general public and many non-pharmaceutical drugs and compounds used in the wellness, anti-aging, and alternative medicine world are made by them. Some practitioners mix other agents into the LipoDissolve solutions but no clear cut benefits has been proven for these ‘cocktail’-like mixtures. I prefer to stay with more pure compounds that use lecithin and cholic acid only as I have never had a negative reaction in a patient yet.

The key to getting a safe and effective outcome with LipoDissolve is one of limited dosing. Keeping injections for the body to less than 50 (total volume of 25 ccs) and in the neck to less than 15 (7.5cc) produces results that appear to have no side effects other than the temporary swelling which is an expected part of the treatment process. I have treated many neck and jowl areas successfully but will not use it for any other facial areas. The use of LipoDissolve injections into the fat pads of the lower eyelids, for example seems dangerous and does not produce a near similar result to what is achieved with the far safer and more predictable lower blepharoplasty procedure.

Dr. Barry Eppley

http://www.eppleyplasticsurgery.com

http://www.ologyspa.com

Clarian North Medical Center, Carmel, Indiana

Clarian West Medical Center, Avon, Indiana

Indianapolis