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Dr. Barry Eppley

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Botox for Glabellar Lines


glabellar wrinkle lines for Botox Dr Barry Eppley IndianapolisThe glabellar frown lines (between the eyebrows) are a top target for Botox injections. They are what the initial studies for FDA approval was based on and continue to be the number one wrinkle area treated by injection. Other than an occasional bruise or temporary soreness in the injected area there are few other adverse problems that happen with injections in this part of the face. The typical effective dose of Botox is in the range of 16 to 24 units by most injectors.

In the September issue of the journal Plastic and Reconstructive Surgery, an article was published entitled ‘Efficacy and Safety of Botulinum Toxin Type A in the Treatment of Glabellar Lines: A Meta-Analysis of Randomized, Placebo-Controlled, Double Blind Trials’. In this paper the authors looked at seven studies comprising nearly 1500 patients to assess the safety and effective endpoint (dose) of botulinum toxin type A for treating glabellar lines. The seven studies included were all randomized, placebo-controlled and double blind trials that used an injection dose of 20 units. Their findings show the the botulinum toxin injected patients had much better improvement in their glabellar wrinkles than the placebo group but, interestingly, the same rate of adverse events.

The incredible popularity and use of neuromuscular modulators in the face using botulinum toxin injections over the past nearly two decades is a statement in and out itself. It is a testament alone that they must be fairly effective and incredibly safe. This study, which amassed well conducted other studies supports what widespread clinical use has shown.

Dr. Barry Eppley

Indianapolis, Indiana

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Dr. Barry EppleyDr. Barry Eppley

Dr. Barry Eppley is an extensively trained plastic and cosmetic surgeon with more than 20 years of surgical experience. He is both a licensed physician and dentist as well as double board-certified in both Plastic and Reconstructive Surgery and Oral and Maxillofacial Surgery. This training allows him to perform the most complex surgical procedures from cosmetic changes to the face and body to craniofacial surgery. Dr. Eppley has made extensive contributions to plastic surgery starting with the development of several advanced surgical techniques. He is a revered author, lecturer and educator in the field of plastic and cosmetic surgery.

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