Plastic Surgery
Dr. Barry Eppley

Explore the worlds of cosmetic
and plastic surgery with Indianapolis
Double Board-Certified Plastic
Surgeon Dr. Barry Eppley

Product Review – Restylane ReFyne and Restylane DeFyne


With over 25 synthetic injectable fillers on the US market it can be argued that how may more do we really need. But each new injectable filler offers some advantage and thus there is room for more. These growing number of injectable fillers has led to the concept of a toolkit of injectable treatments that allows customized use for specific facial aging indications  and applications.

Restylane Refyne and Restylane Defyne Dr Barry Eppley IndianapolisThe most recently approved filler is Restylane Refyne and Restylane DeFyne.  These have been FDA approved for the treatment of nasolabial folds. The main difference with these Restylane products and other hyaluronic acid fillers in in their inherent flexibility due to the proprietary XpresHAn technology. (X = cross-linking, Pres = pressing gels through mesh for calibration, HA = hyaluronic acid) This allows facial expressions (smiling, frowning, etc) to not feel stiff and more natural due to the flexibility of the filler material.  While new to the U.S. the product has been used in Europe for years under the name of  Emervel.

Restylane Refyne is the most flexible and provides support for moderate lines while Restylane Defyne is less flexible and is intended to support deeper lines. Their advantage amongs injectable fillers is their ‘Natural Expression in Motion’. Most patients treated felt that their facial expressions were unaffected and the location of the filler was not detectable.

Dr. Barry Eppley

Indianapolis, Indiana

Dr. Barry EppleyDr. Barry Eppley

Dr. Barry Eppley is an extensively trained plastic and cosmetic surgeon with more than 20 years of surgical experience. He is both a licensed physician and dentist as well as double board-certified in both Plastic and Reconstructive Surgery and Oral and Maxillofacial Surgery. This training allows him to perform the most complex surgical procedures from cosmetic changes to the face and body to craniofacial surgery. Dr. Eppley has made extensive contributions to plastic surgery starting with the development of several advanced surgical techniques. He is a revered author, lecturer and educator in the field of plastic and cosmetic surgery.

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