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Long-Term Fate of Hydroxyapatite Cement in Growing Skulls


Skull reconstruction in young children is almost always done by bone reshaping operations. For common craniofacial deformities like numerous forms of craniosynostosis, the deformed bones are removed and put back in a reshaped fashion to allow for brain growth to continue to mold the developing skull shape. But once the child reaches several years of age treating many skull shape issues is beyond what bone reshaping can reliably do both technically and risk-wise.

This issue of what to do with abnormal skull shape issues, either unoperated on or persistent issues after reconstruction, has always been a bit of a dilemma. In essence how to treat skull contour issues that can not or do not justify a craniotomy and bone reshaping approach. Ideally one would want to use bone grafts but they are both unreliable as a contour method and require a harvest site.

Hydroxyapatite Bone cement Dr Barry Eppley IndianapolisThe synthetic bone substitute, hydroxyapatite cement, offer an alternative to the use of bone grafts. As a synthetic calcium phosphate material, it avoids the need for a harvest site and is an easily moldable putty that is applied and allowed to harden. It has been around from various manufacturers for over twenty years. It was originally and still is FDA-approved for inlay (partial or full-thickness) cranial defects. While it is widely used as an onlay bone contouring material as well I am not aware that it has ever been formally FDA-approved to be used as such.

I have used hydroxyapatite cement in children as a cranial contouring materials now for almost two decades. I have found it to be very useful as skull contouring technique and have never seen a single postoperative problem develop from its use. My original animal studies from way back in 1996 showed that bone started to develop growth along the sides of the material in less than three months after its application. But there has always been the unknown issue of what is its fate decades later and does it in any way cause skull growth issues? The assumption has been that it becomes surrounded by natural bony overgrowth and grows along with the surrounding bone.

Hydroxyapatite Cement in Craniofacial Surgery Long Term Result top view Dr Barry Eppley IndianapolisHydroxyapatite Cement in Craniofacial Surgery Long Term Result left oblioque view Dr Barry Eppley IndianapolisHydroxyapatite Cement inj Craniofacial Surgery Long Ternm result obloique view Dr Barry Epplay IndianapolisA recent patient experience provides some insight into the long-term fate of hydroxyapatite cement. I performed a hypertelorism repair in a 3 year-old child back in 1996. One year after that surgery he has some additional contouring of the brow bones and lower forehead using hydroxyapatite cement. Almost twenty years later he reappeared and wanted some additional forehead, brow and nose contouring surgery. Using his original scalp incision the forehead and brows were exposed and the original hydroxyapatite cement sites were examined. They looked like perfectly normal bone. In comparing the original intraoperative pictures to the present day ones, the hydroxyapatite cement seems to have turned into bone.

While I did not dig into the original implanted site to know for sure, I would think the cement had developed bony overgrowth rather than was replaced by bone. At the least this shows that hydroxyapatite cement in growing children’s skulls appear to be very well tolerated without any adverse growth or bone effects. While this is just a single case observation it does support my original assumption about the long-term fate of hydroxyapatite cements when used as an onlay contouring material in growing skull sites.

Dr. Barry Eppley

Indianapolis, Indiana

Dr. Barry EppleyDr. Barry Eppley

Dr. Barry Eppley is an extensively trained plastic and cosmetic surgeon with more than 20 years of surgical experience. He is both a licensed physician and dentist as well as double board-certified in both Plastic and Reconstructive Surgery and Oral and Maxillofacial Surgery. This training allows him to perform the most complex surgical procedures from cosmetic changes to the face and body to craniofacial surgery. Dr. Eppley has made extensive contributions to plastic surgery starting with the development of several advanced surgical techniques. He is a revered author, lecturer and educator in the field of plastic and cosmetic surgery.

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